Background: The aim of the study is the evaluation of pulmonary nodules seen at multi-slice CT (MSCT) chest in known patients with breast cancer and follow-ups aiming to provide basic features for indeterminate and suspicious pulmonary nodules, evaluating pulmonary nodules assist in assessing the probability that these nodules are indicative of metastasis. Methods: Prospective analysis of 107 female patients, who were known with breast cancer. MSCT chest was done for all cases. Pulmonary nodules were assessed in date and categorized as indeterminate and suspicious nodules, and then after 2 years of follow-up according to nodule behavior and/ or positron emission tomography (PET) CT, they are categorized as benign and malignant nodules. Results: Nodule size, multiplicity, density, shape, and behavior, there was a strong association with the type of nodule, as indicated by a P-value of less than 0.001. The cut-off size and density of pulmonary nodules were 6.5 mm and -99.5 HU respectively with high specificity in differentiating malignant from benign nodules. Conclusions: A multi-slice CT chest is imperative in the diagnosis of pulmonary nodules in cases of breast cancer. Nodule characteristics and behavior are important parameters for the provisional diagnosis, whether benign or malignant.