Given the substantial evidence and growing concern for the potential carcinogenic effects of children’s exposure to ionizing radiation during computed tomography (CT) examinations, appropriate use of acquisition parameters is essential to attain diagnostic image quality at the lowest possible radiation dose. The objective of this article is to provide a systematic review to the pediatric imaging team members on how to manage pediatric CT doses and control the essential scanning parameters. The article also highlights other key factors that can be easily used to ensure safe imaging. Some practical tips and technical considerations are provided to be simply incorporated into clinical practice. Optimization of CT imaging is a dynamic process and needs understanding and engagement of all pediatric imaging team members, as keeping our children safe should be the ultimate goal in CT imaging.