Background
Mast cells plays critical role in inflammatory diseases, including cardiovascular and metabolic diseases and their associated complications. These cells exert their physiological and pathological activities by releasing granules containing histamine, cytokines, chemokines, and proteases, including mast cell-specific chymases and tryptases
Method
70 Type 2 diabetic obese patients attending the Diabetes and Endocrinology clinic in Kasr El Ani hospital compared to 15 healthy controls
Results
Statistical significant difference between patients and control regarding BMI, glucose,cholesterol, HDL, LDL,tryptase (p<0.001) ,triglycerides(p=0.001) Tryptase statistically correlated with BMI,fastingglucose,A1C,triglycerides(p=0.014,r=0.031)/(p=0.012,r=0.297)/(p<0.001,r=0.862),(p=0.039,r=0.247) Higher mean level of tryptase in patients with diabetic complications mainly in retinopathy (32.32 ng/ml)
Conclusion
Tryptase participate in the pathogenesis of diabetes mellitus and its complication targeting mast cells as novel therapy for diabetes requires further investigations