Purpose. Dry eye is the most common complication after LASIK procedure and is associated with corneal denervation. We conducted this study to compare the effect of MK assisted Lasik and Femtolasik on dry eye parameters. Patients and Methods: In this prospective, nonrandomized, comparative study, 160 patients with myopia and astigmatism refractive surgery candidates MK assisted lasik and femtolasik were examined, the groups were age and sex matched. Schirmer testing, tear breakup time (TBUT), corneal staining were performed one week pre-operative and at 1 week, 1, 3 and 6 months postoperatively. Inclusion/exclusion criteria: Patients older than 18 years with stable refraction, normal ophthalmic examination except for refractive errors planned residual stromal bed thickness more than 300 um. pregnant patients and patients with autoimmune diseases, previous ocular surgery were excluded from the study. Results: There was no significant deviation in Schirmer test. There was no significant deviation in cornea staining scores, there was no significant deviation in tear break up time test between the two groups throughout the 6 months post-operative. There was obvious decrease in Schirmer test and TBUT, corneal fluorescein staining post-operative relative to pre-operative values at first week. Conclusions: Both FS- and MK-assisted LASIK reduced Schirmer basic test TBUT and increased corneal staining. There was no significant difference in Schirmer test, TBUT, corneal fluorescein staining scores between the two groups.