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389793

Hybridization of Thiazole and Pyrazoline heterocycles, and the Biological Activities of Their Hybrid Scaffolds

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Section B: Pharmaceutical Analytical and Organic Chemistry, Medicinal Chemistry, and Biochemistry

Abstract

Thiazoles and pyrazolines represent a class of heterocyclic compounds with attractive and considerable interest in medicinal chemistry due to their diverse pharmacological activities. Hybridizing thiazole and pyrazoline moieties has emerged as an innovative approach to drug discovery, enabling the synthesis of novel compounds with enhanced therapeutic potential. The hybridization of thiazole and pyrazoline scaffolds allows for incorporating different functional groups and substitution patterns, which can influence the compound's bioactivity, selectivity, and pharmacokinetic profile. The hybridization of these two heterocyclic moieties has resulted in compounds with diverse pharmacological properties, such as antimicrobial, antitumor, anti-inflammatory, and antioxidant. Furthermore, thiazolyl-pyrazolines' ability to interact with specific molecular targets, such as enzymes, receptors, or signalling pathways, makes them attractive candidates for drug development. This abstract provides an overview of the hybridization strategy and highlights the medicinal chemistry aspects and biological activities of thiazolyl-pyrazolines.

DOI

10.21608/erurj.2024.236943.1076

Keywords

thiazole, Pyrazoline, Hybridization, Anti-proliferative

Authors

First Name

Mariam

Last Name

Fakhry

MiddleName

M

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr, Egypt

Email

mariam-medhat@eru.edu.eg

City

-

Orcid

0000-0002-1855-6918

First Name

Amr

Last Name

Mattar

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr, Egypt

Email

amr-a-mattar@eru.edu.eg

City

-

Orcid

-

Volume

3

Article Issue

4

Related Issue

51327

Issue Date

2024-10-01

Receive Date

2023-09-29

Publish Date

2024-10-01

Page Start

1,738

Page End

1,760

Print ISSN

2812-6211

Online ISSN

2812-622X

Article File

ERURJ_Volume 3_Issue 4_Pages 1738-1760.pdf

PDF . 520.5kB

Link

https://erurj.journals.ekb.eg/article_389793.html

Detail API

https://erurj.journals.ekb.eg/service?article_code=389793

Order

389,793

Type

Mini-review

Type Code

2,450

Publication Type

Journal

Publication Title

ERU Research Journal

Publication Link

https://erurj.journals.ekb.eg/

MainTitle

Hybridization of Thiazole and Pyrazoline heterocycles, and the Biological Activities of Their Hybrid Scaffolds

Details

Type

Article

Created At

29 Dec 2024