Cardiovascular diseases including hypertension and hypercholesterolemia considered to be two of the most chronic, age-related risk factors. Both risk factors controlling process may require a combination of lifestyle modification and pharmaceutical medication either single or combined. Appropriate lifestyle changes may help to control some forms of hypertension as excess body fat is a major contributor to hypertension, along with dietary salt, alcohol, and inactivity. Most cases of hypertension accompanied by hypercholesterolemia require a single or combination of antihypertensive agents e.g. diuretics, angiotensin-converting enzyme inhibitors, calcium channels blockers, and/or angiotensin II receptor blockers with antihyperlipidemic agents e.g. fibrates, or statins. The pharmaceutical product contains telmisartan (TMS) and rosuvastatin calcium (RVS) in one tablet under the trade name of Telrose^® used for the treatment of cardiovascular including hypertension and hypercholesterolemia. This study examines various analytical approaches, such as UV-visible spectroscopy, spectrofluorimetric, chromatographic, electrochemical, and capillary electrophoresis techniques, for quantifying TMS and RVS in their fixed-dose pharmaceutical formulation and other matrices. The comparative use of various analytical methods for quantifying TMS and RVS is discussed in this review. Further analytical research for estimating TMS and RVS may be successfully conducted using the information presented in this review paper