In the present review article, the two genoprotective species Acacia auriculiformis and A. pennata, which are native to Australia and Southeast Asia, respectively, are the subjects of the phytochemical and pharmacological investigations gathered and summarized in the current review paper. Acacia is the largest genus of the family Leguminosae with myriad valuable medicinal plants. Both of them have been employed for various ailments in traditional medicine such as headaches, rheumatism, dry cough, and fever. They possess major pharmacological activities such as antioxidant, anti-genotoxic, hepatoprotective, antiviral, and antifungal properties which were previously reported for both. A. Auriculiformis possessed antimalarial, cestocidal, anti-filarial, and spermicidal activities, whereas A. pennata showed anti-nociceptive, anti-inflammatory, and anti-transcription activity. Triterpenoid saponin and flavonoids are the primary phytochemical compounds isolated from different parts of A. auriculiformis and leaves of A. pennata, respectively. This review will increase the potential nutraceutical applications of both plants and their future anticipation in the area of clinical medicine.