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296908

Dysregulation of Apoptotic Genes in Polycystic Ovarian Syndrome Patients Undergoing In-vitro Fertilization

Article

Last updated: 29 Dec 2024

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Subjects

-

Tags

Section B: Pharmaceutical Analytical and Organic Chemistry, Medicinal Chemistry, and Biochemistry

Abstract

Polycystic Ovary Syndrome (PCOS) is a common endocrine-reproductive disease in females. Cell apoptosis plays an important role in follicular development, mainly in egg production, oocyte degeneration, follicle selection, or even follicle atresia. It also serves an important part in the embryo's early growth and differentiation into a complete organism. PCOS is a condition that is known to be caused by alterations in cell development and cell death factors, as well as oxidative stress, resulting in follicular interruptions and immature follicles. Apoptosis is a natural homeostatic process that helps the tissue remove the growing number of unwanted cells that are harmed during development, growth, or senescence. Caspases, an inhibitor of apoptosis proteins, the B cell lymphoma (Bcl)-2 gene family, the tumor necrosis factor (TNF) receptor superfamily, and the p53 gene are all participating and/or cooperating in the apoptosis pathway. Microarray data analysis of PCOS databases obtained from GEO datasets was performed to identify significant dysregulated apoptotic genes in PCOS oocytes compared to controls.

DOI

10.21608/erurj.2023.200907.1016

Keywords

polycystic ovary syndrome (PCOS), In vitro fertilization (IVF), apoptosis

Authors

First Name

Ghadir

Last Name

Sayed

MiddleName

A.

Affiliation

Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University, Cairo 11829, Egypt

Email

ghadir-ali@eru.edu.eg

City

-

Orcid

-

First Name

Abdullah

Last Name

Radwan

MiddleName

F.

Affiliation

Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University, Cairo 11829, Egypt

Email

ph.abdullahfathy@gmail.com

City

-

Orcid

0000-0002-3731-1561

First Name

Ahmed

Last Name

Reda

MiddleName

M.

Affiliation

Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University, Cairo 11829, Egypt

Email

ahmed-mostafa@eru.edu.eg

City

-

Orcid

-

First Name

Aya

Last Name

Salman

MiddleName

T.

Affiliation

Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University, Cairo 11829, Egypt

Email

aya_tarek@eru.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Youssef

MiddleName

A.

Affiliation

Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University, Cairo 11829, Egypt

Email

ahmed-abdelghany@eru.edu.eg

City

-

Orcid

-

First Name

Gamil

Last Name

Abd-Allah

MiddleName

M.

Affiliation

Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University, Cairo 11829, Egypt

Email

gamil-abdalla@eru.edu.eg

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

41033

Issue Date

2023-04-01

Receive Date

2023-03-18

Publish Date

2023-04-01

Page Start

320

Page End

330

Print ISSN

2812-6211

Online ISSN

2812-622X

Article File

ERURJ_Volume 2_Issue 2_Pages 320-330.pdf

PDF . 319.0kB

Link

https://erurj.journals.ekb.eg/article_296908.html

Detail API

https://erurj.journals.ekb.eg/service?article_code=296908

Order

296,908

Type

Original Article

Type Code

2,445

Publication Type

Journal

Publication Title

ERU Research Journal

Publication Link

https://erurj.journals.ekb.eg/

MainTitle

Dysregulation of Apoptotic Genes in Polycystic Ovarian Syndrome Patients Undergoing In-vitro Fertilization

Details

Type

Article

Created At

29 Dec 2024