In order to encourage and facilitate collecting literature review for other researchers who will have studies related to the presented compounds, the following article was introduced by presenting a mini-review of the different methods applied for quantitative determination of some drugs affecting GIT namely, Lansoprazole (LAN) co-formulated with Clarithromycin (CLR) and Tinidazole (TD), and Phloroglucinol (PHG) and Trimethylphloroglycinol (TMG) combination, in their drug mixture forms using different analytical techniques. Helicobacter pylori (H. Pylori) is a fairly prevalent infection that disrupts the stomach, causing several annoyances signs such as chronic gastritis, peptic ulcers, and gastric cancer. Lately, it has been shown that COVID-19 patients' gastrointestinal symptoms are negatively impacted by H. Pylori infection. An effective triple therapy regimen, which typically includes antibiotics and stomach protection, is required to eradicate this bacterial infection. This study discussed the pharmacopeia methods applied for the studied drugs in addition to different techniques which were used for simultaneous determination of the presented compounds in their mixture formulations; including spectrophotometric (UV and visible), electrochemical, in addition to chromatographic (TLC and HPLC) methods either in a biological fluid or in their pharmaceutical dosage forms.  All the discussed approaches in this review were applied and validated following the ICH guidelines. Some of these methods were accomplished according to the green chemistry and evaluated with the green assessment approaches.