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283375

Does the price matter? potency comparative study for different Ceftriaxone generics in the Egyptian market

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Section E: Microbiology and Immunology

Abstract

There are a lot of ceftriaxone sodium generics in the Egyptian market with a huge variation in prices, this raises a tremendous question mark, does the difference in prices reflect a difference in potency? So, we made a small-scale experiment to test generics potencies using the antibiotic agar diffusion method similar to the antibiotic assay method with its graphical and mathematical calculations. This experiment was in a form of a comparative study of ten ceftriaxone sodium generics in the Egyptian market using antibiotic agar diffusion against a standard strain of Staphylococcus aureus ATCC 977 as evaluator microorganism to test the antimicrobial effect of each generic by measuring Inhibition zone diameter (IZD) they leave on pre-inoculated agar plates; Considering the highest priced generic we purchased from the Egyptian market, which was generic A as a reference substitute for pure ceftriaxone sodium which couldn't be afforded in this study. Our results revealed that there was a significant difference in potency, but curiously those differences were not correlated to the prices of the generics.

DOI

10.21608/erurj.2023.188589.1007

Keywords

Ceftriaxone sodium, Antibiotic resistance, Egyptian market, antibiotic agar diffusion method, potency comparison

Authors

First Name

Mohamed

Last Name

abdelaziz

MiddleName

Taha

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

mohammed-taha@eru.edu.eg

City

-

Orcid

-

First Name

Nagwa

Last Name

Mohamed

MiddleName

Osama

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

nagwa-osama@eru.edu.eg

City

Cairo

Orcid

-

First Name

Ahmed

Last Name

ElKhatib

MiddleName

Mohamed

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

ahmed-elkhatib@eru.edu.eg

City

Cairo

Orcid

-

First Name

Yehia

Last Name

Mahmoud

MiddleName

Abdelmoniem

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

yehia-abdelmoniem@eru.edu.eg

City

Cairo

Orcid

-

First Name

Marah

Last Name

Hussein

MiddleName

Moustafa

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

marah-hussein@eru.edu.eg

City

Cairo

Orcid

-

First Name

Esraa

Last Name

Hassan

MiddleName

Korayem

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

esraa-karim@eru.edu.eg

City

Cairo

Orcid

-

First Name

Amira

Last Name

Saad

MiddleName

Gamal

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

amira-gamal-saad@eru.edu.eg

City

Cairo

Orcid

-

First Name

Dalia

Last Name

El-dammasy

MiddleName

Ali

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

daliadamasy@eru.edu.eg

City

Cairo

Orcid

-

First Name

Sara

Last Name

Azmy

MiddleName

Wafdy

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202044@eru.edu.eg

City

Cairo

Orcid

-

First Name

Amira

Last Name

Elsayed

MiddleName

Mohamed

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202262@eru.edu.eg

City

Cairo

Orcid

-

First Name

Ahmed

Last Name

Elsayed

MiddleName

Adel

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202036@eru.edu.eg

City

Cairo

Orcid

-

First Name

Sarah

Last Name

Abdel Aal

MiddleName

Hussein

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202171@eru.edu.eg

City

Cairo

Orcid

-

First Name

Tasnim

Last Name

Abdelhamid

MiddleName

Mohammed

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202313@eru.edu.eg

City

Cairo

Orcid

-

First Name

Kholoud

Last Name

Mohamed

MiddleName

Farag

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202098@eru.edu.eg

City

Cairo

Orcid

-

First Name

Fady

Last Name

Ishak

MiddleName

Namr

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202102@eru.edu.eg

City

Cairo

Orcid

-

First Name

Amira

Last Name

Elsayed

MiddleName

Adel

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202231@eru.edu.eg

City

Cairo

Orcid

-

First Name

Ziad

Last Name

Elsaied

MiddleName

Yasser

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202124@eru.edu.eg

City

Cairo

Orcid

-

First Name

Aya

Last Name

Ali

MiddleName

Mohamed

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202305@eru.edu.eg

City

Cairo

Orcid

-

First Name

Yara

Last Name

Ghrseldin

MiddleName

Hany

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202327@edu.eru.eg

City

Cairo

Orcid

-

First Name

Ahmed

Last Name

Amer

MiddleName

Sheref

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

212115@eru.edu.eg

City

Cairo

Orcid

-

First Name

Mark

Last Name

Mahrous

MiddleName

Asaad

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202275@eru.edu.eg

City

Cairo

Orcid

-

First Name

Hager

Last Name

Ibrahim

MiddleName

Abdelkader

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

212112@eru.edu.eg

City

Cairo

Orcid

-

First Name

Habiba

Last Name

Hamed

MiddleName

Hany

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202361@eru.edu.eg

City

Cairo

Orcid

-

First Name

Mariam

Last Name

Mostafa

MiddleName

Mohammad

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202158@eru.edu.eg

City

Cairo

Orcid

-

First Name

Norhan

Last Name

Gamel

MiddleName

Sobhy

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

212143@eru.edu.eg

City

Cairo

Orcid

-

First Name

Noura

Last Name

Khalil

MiddleName

Elsayed

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202315@eru.edu.eg

City

Cairo

Orcid

-

First Name

Shahd

Last Name

Ibrahim

MiddleName

Hany

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202336@eru.edu.eg

City

Cairo

Orcid

-

First Name

Nada

Last Name

Ibrahim

MiddleName

Medhat

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202214@eru.edu.eg

City

Cairo

Orcid

-

First Name

Hanan

Last Name

Abdelmotalb

MiddleName

Hatem

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202196@eru.edu.eg

City

Cairo

Orcid

-

First Name

Maria

Last Name

Mina

MiddleName

Mounir

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202079@eru.edu.eg

City

Cairo

Orcid

-

First Name

Abdallah

Last Name

Hosni

MiddleName

Ahmed

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

212009@eru.edu.eg

City

Cairo

Orcid

-

First Name

Hanaa

Last Name

Khalifa

MiddleName

Mahmoud

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202139@eru.edu.eg

City

Cairo

Orcid

-

First Name

Hadir

Last Name

Shaaban

MiddleName

-

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202225@eru.edu.eg

City

Cairo

Orcid

-

First Name

Ahmed

Last Name

Ibrahim

MiddleName

Mounir

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

212010@eru.edu.eg

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Elshahedy

MiddleName

Ashraf

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202343@eru.edu.eg

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Abdelkader

MiddleName

Ahmed

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202290@eru.edu.eg

City

Cairo

Orcid

-

First Name

Fatma

Last Name

ElBadrawy

MiddleName

Elzahraa

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202217@eru.edu.eg

City

Cairo

Orcid

-

First Name

Nada

Last Name

Ghareeb

MiddleName

Elaraby

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202056@eru.edu.eg

City

Cairo

Orcid

-

First Name

Tasneem

Last Name

Nagy

MiddleName

Hussein

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202243@eru.edu.eg

City

Cairo

Orcid

-

First Name

Wesam

Last Name

Mohamed

MiddleName

Saeed

Affiliation

Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

202005@eru.edu.eg

City

Cairo

Orcid

-

First Name

Ibrahiem

Last Name

Abdelrahman

MiddleName

-

Affiliation

PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

Email

222206@eru.edu.eg

City

Cairo

Orcid

-

First Name

Tharwat

Last Name

El-khamissy

MiddleName

-

Affiliation

Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

Email

tharwat-elkhamissy@eru.edu.eg

City

Cairo

Orcid

-

Volume

2

Article Issue

1

Related Issue

39368

Issue Date

2023-01-01

Receive Date

2023-01-22

Publish Date

2023-01-01

Page Start

210

Page End

218

Print ISSN

2812-6211

Online ISSN

2812-622X

Article File

ERURJ_Volume 2_Issue 1_Pages 210-218.pdf

PDF . 443.4kB

Link

https://erurj.journals.ekb.eg/article_283375.html

Detail API

https://erurj.journals.ekb.eg/service?article_code=283375

Order

7

Type

Original Article

Type Code

2,445

Publication Type

Journal

Publication Title

ERU Research Journal

Publication Link

https://erurj.journals.ekb.eg/

MainTitle

Does the price matter? potency comparative study for different Ceftriaxone generics in the Egyptian market

Details

Type

Article

Created At

29 Dec 2024