This article discussed several analytical techniques which concerned with determination of linagliptin and empagliflozin to help every analyst to know the latest analytical methods used for determination of the studied drugs especially not recorded in pharmacopoeia and also mentioned the physiochemical characters and the pharmacological action of the studied drugs. Linagliptin is a dipeptidyl peptidase-4 inhibitor that used for treatment of type-II diabetes and empagliflozin is a sodium-glucose co transporter-2 (SGLT-2) inhibitor and also is used for type-II diabetes treatment. The review discussed techniques used for determination each drug quantitively involving spectrophotometric (UV and visible), spectrofluorimetric, electrochemical and chromatographic (TLC and HPLC) methods either in biological sample or in the pharmaceutical dosage forms. All methods included in the review are validated and constructed according to ICH guidelines. Distribution of analytical methods for empagliflozin and linagliptin was performed and it was obvious that HPLC technique was the most developed methods followed by spectroscopy and electrochemical methods. Spectroflorimetric methods were the most suitable methods for determination either linagliptin or empagliflozin in biological samples as the spectroflorimetric technique has high sensitivity.