This study examines the relationship between psychological stress and academic adjustment among female students at the University College of Bernie, Al-Taif University. A sample of 354 students from various academic years and disciplines was selected, and data were collected using a structured questionnaire. The results indicate that, on moderate, the levels of psychological stress and academic adjustment among the students were moderate, with notable differences across academic years and fields of study. Third-year students experienced the highest levels of psychological stress, likely due to the increasing demands of their coursework. In contrast, second-year students showed the highest levels of academic adjustment, possibly reflecting their adaptation to the university environment after their initial year. The analysis revealed a clear negative relationship between psychological stress and academic adjustment. As psychological stress increased, students' ability to adapt academically tended to decline, highlighting the negative impact of stress on their academic performance and overall well-being. Additionally, the findings showed slight differences between academic departments. Students in science and technology fields faced more significant challenges in adjusting academically compared to their peers in the humanities, suggesting that the specific demands of these fields may contribute to different stress levels and adjustment difficulties. Based on these findings, the study recommends developing targeted support programs, including workshops focused on coping strategies and stress management. These initiatives aim to enhance students' academic adjustment and improve their overall university experience, providing a more supportive environment for female students at Al-Taif University