The present study search on 21st century digital literacy and its relationship with students' awareness of the physics application in our everyday use of lens, optics, electricity and energy. The study sampled four hundred and eighty-four (484) education students' across all teacher-producing colleges and universities in Kwara state, Nigeria using a convenient sampling technique. An adapted and researchers' designed instruments were used to elicit data from the respondents. A Partial least square structural equation modeling approach was used and the data collected were analyzed via SmartPLS software version 4.0.9.2. The results of the study revealed that all three dimensions of 21st digital literacy were significantly related to students' awareness of physics applications in our everyday life. The study also found that necessary condition analysis and partial least square p-values result indicated that 21st digital literacy can influence significantly the students' awareness of physics applications in the use of lens and optics, and electricity and energy.