Background: Whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), consists of genetically diverse species known to cause significant destruction in several crops around the world. The vegetable cucumber (Cucumis sativus L.) is a popular one and has a flavor that is both fresh and unique. Cucumbers, like other fruits and vegetables grown commercially, have long been the subject of research efforts to increase their economic viability. Aim: The investigation was carried out to study the influence of enzymes and phytochemical components of three varieties of cucumber plant (F1 hybrid Muluki, F1 hybrid Hayal, and F1 hybrid Basha) on the population dynamics of whitefly (Bemisia tabaci Genn.). Results and conclusion: Concerning phenoloxidase enzyme, peroxidase, GST enzyme, α-esterases, β-naphtholα-naphthol, ions (N, P and K) and total proteins. The highest level of the enzyme was found in Muluki and Hayal, while moderate amount was found in Basha variety. The obtained results showed level of influence pronounced differences in the population dynamics of this pest species on the tested plant varieties. A positive relationship between protein and carbohydrate contents. According to these results, resistant varieties can be recommended in the integrated pest management programs for depressing tested pests on cucumber plants.