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311795

Prevalence of thrombocytosis in epidermolysis bullosa patients

Article

Last updated: 29 Dec 2024

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Tags

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Abstract

Epidermolysis bullosa (EB) is a rare inherited genetic disease characterized by extreme fragility of the skin and mucous membranes, which gives rise to the formation of blisters and ulcers following minor trauma. As EB is a rare disease, the reported studies regarding epidermolysis bullosa are very limited. This study was aimed to investigate the alterations in the hematologic parameters and assess the prevalence of thrombocytosis in children suffering from EB. Eight EB patients aged (3 to 12 years) from the Dermatology Unit of King Khalid Hospital (KKH), Hail city, Saudi Arabia were included in this study.
The hematological changes of EB patients were characterized by a significant decrease in the total erythrocytes (RBCs) count, hemoglobin (Hb), hematocrits (PCV) percentage, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH). The predominance of thrombocytosis and lymphocyte production was verified in this study. Moreover, Staphylococcus aureus and Streptococcus epidermidis were the most isolated microorganisms from wound cultures of EB patients. In conclusion, thrombocytosis, anemia, and/or poor nutritional status seem to be common complications in nearly all cases of EB.

DOI

10.21608/ijtar.2023.140535.1004

Keywords

Epidermolysis Bullosa, Hematologic parameters, Thrombocytosis, Anemia

Authors

First Name

Rasha

Last Name

El sayed

MiddleName

Aly

Affiliation

cairo, egypt

Email

rs.elsayed@gmail.com

City

cairo

Orcid

https://orcid.org/00

First Name

Sanaa

Last Name

Mahmoud

MiddleName

-

Affiliation

zoology Department, Faculty of Science, Beni Suef University

Email

sabdeltwab@yahoo.com

City

cairo

Orcid

-

First Name

Madiha

Last Name

Alkhmale

MiddleName

-

Affiliation

Hail, faculty of Science

Email

algnh-055@hotmail.com

City

Hail

Orcid

-

First Name

Ibtisam

Last Name

Al-Shammari

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Hail Univ., Saudi Arabia

Email

rs.elsayed@hotmail.com

City

Hail

Orcid

-

First Name

Amani

Last Name

Bakawi

MiddleName

-

Affiliation

Hail

Email

k.ma777@hotmail.com

City

Hail

Orcid

-

Volume

2

Article Issue

1

Related Issue

36191

Issue Date

2023-06-01

Receive Date

2022-06-04

Publish Date

2023-06-01

Page Start

85

Page End

88

Print ISSN

2812-5878

Online ISSN

2812-5886

Link

https://ijtar.journals.ekb.eg/article_311795.html

Detail API

https://ijtar.journals.ekb.eg/service?article_code=311795

Order

311,795

Type

Brief Communications Arising and Corrections

Type Code

2,370

Publication Type

Journal

Publication Title

International Journal of Theoretical and Applied Research

Publication Link

https://ijtar.journals.ekb.eg/

MainTitle

Prevalence of thrombocytosis in epidermolysis bullosa patients

Details

Type

Article

Created At

29 Dec 2024