Ibuprofen (Ibu), a non-steroidal anti-inflammatory drug, is widely used for pain and inflammation relief. Bee pollens (BPs) are a natural honey bee product. They are rich in flavonoid and phenolic compounds, which possess antioxidant activities that prevent free radicals from being generated in the biological system. Date palm pollen (DPP) is an important source of natural antioxidants as it has a lot to do with the content of vitamins and flavonoids. This study's objective was to investigate the combined effects of DPP and BP against Ibu-induced toxicity on the hematological and oxidative stress parameters in male albino rats over one month. Seven groups of forty-two male albino rats were created. A control group is represented by the first group, the second group was administrated with Ibu (60 mg/kg body wt.) the third group was supplemented with BP (100 mg/kg body wt.), the fourth group was supplemented with DPP (100 mg/kg body wt.), the fifth group was treated with BP before Ibu, the sixth group was treated with DPP before Ibu, whereas the seventh group was treated with BP combined with DPP before Ibu. Results indicated that Ibu induced significantly altered hematological and oxidative parameters compared to control. DPP and BP normalized the hematological indices but affected the oxidative stress parameters. combined DPP and BP treatment mitigated Ibu toxicity, normalizing hematological indices, and significantly altering oxidative stress parameters. Therefore, BP and DPP alongside Ibu offer protective effects against Ibu-induced haematological and oxidative stress damage in rats. Also, these findings provide insights into BP and DPPs antioxidants, and protective influence against Ibu toxicity.