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320349

One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines

Article

Last updated: 29 Dec 2024

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Subjects

-

Tags

Chemistry

Abstract

In this work, we synthesized a novel arylidene malononitrile 3 via the treatment of o-alkyl vanillin derivative 1 with malononitrile 2 in the presence of triethylamine (TEA) as a catalyst. The arylidene malononitrile 3 was subjected to react under one-pot multicomponent reaction (MCR) condition with respective methylarylketones 4a-f and sodium ethoxide 5 in ethanol to afford a new series of 2-(4-(6-aryl-3-cyano-2-ethoxypyridin-4-yl)-2-methoxyphenoxy)-N-phenylacetamides 6a-f. The structure of the new products was assured via spectral and elemental analysis. The reaction mechanism was suggested. 

DOI

10.21608/sjsci.2023.227734.1111

Keywords

O-alkyl vanillin, pyridine derivatives, arylidene, N-phenylacetamide, multicomponent reaction

Authors

First Name

Hayam

Last Name

Mohammed

MiddleName

H.

Affiliation

Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

Email

hayamhossni95@yahoo.com

City

-

Orcid

-

First Name

Eman A.

Last Name

Ahmed

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

Email

abdala_15@yahoo.com

City

-

Orcid

-

First Name

Bahgat

Last Name

Hussein

MiddleName

R. M.

Affiliation

Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

Email

bahgat.ramadan@yahoo.com

City

sohag

Orcid

0000-0002-6725-4879

First Name

Omran

Last Name

Abdellah

MiddleName

A.

Affiliation

Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt

Email

omran3646@gmail.com

City

Sohag

Orcid

0000-0001-9890-2114

Volume

9

Article Issue

1

Related Issue

42891

Issue Date

2024-03-01

Receive Date

2023-08-07

Publish Date

2024-01-01

Page Start

76

Page End

80

Print ISSN

2357-0938

Online ISSN

2974-4296

Article File

SJSCI_Volume 9_Issue 1_Pages 76-80.pdf

PDF . 338.4kB

Link

https://sjsci.journals.ekb.eg/article_320349.html

Detail API

https://sjsci.journals.ekb.eg/service?article_code=320349

Order

320,349

Type

Regular Articles

Type Code

2,359

Publication Type

Journal

Publication Title

Sohag Journal of Sciences

Publication Link

https://sjsci.journals.ekb.eg/

MainTitle

One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines

Details

Type

Article

Created At

29 Dec 2024