Chemotherapy-induced nausea and vomiting are prevalent adverse effects experienced by cancer patients, particularly children undergoing treatment for gastrointestinal cancer. Aim: This research sought to ascertain the effect of peppermint inhalation versus slow-stroke back massage on chemotherapy-induced nausea and vomiting among children with gastrointestinal cancer. Method: A randomized controlled trial design was employed for this investigation. The study encompassed 90 pediatric patients with gastrointestinal cancer undergoing chemotherapy, recruited from the Pediatric Oncology Department at the South Egypt Cancer Institute, Assiut University. Participants were randomly assigned to three groups: a peppermint inhalation group, a slow-stroke back massage group, and a control group. Data collection involved the utilization of a structured questionnaire and the Rhodes Index of Nausea and Vomiting Likert Scale. Results: In terms of vomiting, a significant proportion of children in the peppermint inhalation group (80%) and massage group (70%) did not experience vomiting, in stark contrast to only 3.3% in the control group. Regarding nausea, the peppermint inhalation group (86.6%) and massage group (76.7%) did not encounter nausea, contrasting starkly with only 3.3% in the control group. Conclusion: Peppermint inhalation and slow-stroke back massage demonstrate substantial antiemetic efficacy in mitigating chemotherapy-induced nausea and vomiting in children with gastrointestinal cancer. The study recommends the integration of peppermint inhalation and slow-stroke back massage as standard interventions for managing chemotherapy-induced nausea and vomiting in pediatric patients with gastrointestinal cancer