Background: Work hazards are confounding factors for staff and patient safety. Their management and its improvement are targets of the intended organization as World Health Organization and International Labour Organization for high quality of patients care and for improving quality of work live of nurses and their retention. That could be improved through training nurses on work-related hazards. Hence, this study aimed to assess work-related hazards training program effect on quality of nursing work life and turnover intention among staff nurses at Suez Canal University Hospital. Methods: The data of current study were collected at Suez Canal University Hospital from staff nurses using work-related hazards knowledge and practice questionnaires, quality of nursing work life questionnaire, and the anticipated turnover intention scale. The quasi-experimental design was applied to conduct this study. Result: Statically significant differences were found before and after the work-related hazards training program for the satisfied level of knowledge (20.7% before, 91.8% immediate post, and 83.7% at follow-up. The corresponding figures for actual hazards were (54.9% reported high scores before, 37.0% immediate post, and 44.0% at follow-up), preventive measures (28.6% before, 74.5% immediate post, and 67.4% at follow-up), quality of work life (83.2% before, 85.3% immediate post, and 88.0% at follow-up) and turnover intention (56.0% before, 50.5% immediate post, and 53.0% at follow-up). Conclusion:  There  is  a  significant  improvement  of  knowledge and  preventive measures  practice  of  staff  nurses  regarding  work  hazards  in addition to shrinking exposure level to actual hazards  along  with training  program  phases.  The same positive effect of program was found regarding nursing turnover intention and quality of work life. Recommendations: Conducing regular and updated training program of each types of work hazards management for staff nurses is required. Also, the organizational intervention is endorsed for their management too. Key words: Quality of work life, Preventive measures, Turnover intention, Work hazards.