Background: Coronary Artery Bypass Graft is a surgical procedure that diverts blood flow away from the narrowed and clogged arteries to improve blood supply to the heart. Patient education after CABG aids the patients to deal with their condition and with new alterations in their life style to inhibit repeated revascularization. The aim of this study was to assess the level of knowledge and self-efficacy for post CABG surgery patients. Design: A descriptive research design was utilized, Setting: the study was conducted at the Cardio-Thoracic Surgery outpatient Clinic in Suez Canal University Hospitals, Sample: A purposive sample of 64 patients, Tools: Tool (1) Structured interview questionnaire: It included four parts: Part 1: Socio-demographic characteristics assessment, Part 2: Medical history assessment - Part 3: Smoking history Part 4: Assessment the level of knowledge about disease, risk factors, and it's treatment. Tool (2): Assessment of self-efficacy for post CABG surgery patients questionnaire. Results: The study revealed that all of the studied patients had unsatisfactory knowledge about disease and its' treatment and un confident in their self-efficacy Conclusion: Level of patient's knowledge was un satisfactory and Patient's self- efficacy was un confident. Recommendations: Develop posters and booklets for patient about treatment and complications of CABG to improve level of knowledge and Develop an individualized care plan for each patient to increase their self efficacy.