Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that associated with high morbidity and mortality and causing a burden on the quality of life (QOL). Aim of the study: To explore the correlates of health-related quality of life among patients with systemic lupus erythematosus. Design: A descriptive correlational research design was used in this study. Setting: The study was conducted in Rheumatology and Rehabilitation outpatient clinics at Suez Canal University Hospitals in Ismailia City, Egypt. Subjects: A convenient sample of 60 patients with systemic lupus erythematosus. Tool of data collection: Data was collected by using three tools; tool I: Structured interviewing questionnaire to assess sociodemographic data and medical condition, tool II: Adherence of patient to therapeutic regimen questionnaire to assess patient's adherence to therapeutic regimen and tool III: Short Form Health Survey 36 (SF-36) to assess QOL. Results: The mean age of studied patients was 31.96±9.20 years. 75% of the studied patients had high QOL. There was a significant positive correlation between total QOL and total adherence of the studied patients to therapeutic regimen with p value 0.01. There was statistically significant positive relation between the studied patients' QOL level and duration of suffering of SLE with p value 0.022. Conclusion: There was a significant positive correlation between total QOL and total adherence of the studied patients to therapeutic regimen and there was significant positive relation between the studied patients' QOL level and duration of suffering of disease. Recommendations: Educational guidelines to improve good correlates of QOL were recommended.