Polycystic ovarian syndrome (PCOS) is a common heterogeneous disorder with uncertain-etiology. PCOS is associated with complex symptomatology and various clinical presentations, resulting in worsened quality of life (QOL). Aim of the study: To assess the quality of life among women with polycystic ovarian syndrome at Suez Canal university hospital. Research design: A descriptive design was utilized in this study. Study sample: A convenient sample of 115 women diagnosed with polycystic ovarian syndrome was selected from outpatient clinic of gynecology at Suez Canal University Hospital in Ismailia Governorate. Tools of data collection: A Structured interviewing questionnaire about personal, menstrual, obstetric, and gynecological history, and quality of life questionnaire for women with polycystic ovarian syndrome were used for data collection. Results: - Almost half (49.6%) of the studied women were nulligravida, 67.8% of them were nullipara and more than two-thirds (70.4%) didn't have children, 71.3% had an irregular menstrual cycle and the majority of them (87.8%) suffered from infertility. Less than half of the studied women (44.4%) had poor quality of life, more than half (52.1%) had average quality of life while only 3.5% had good quality of life. Conclusion: PCOS has a negative impact on women's overall QOL. PCOS affects all the domains of QOL by different grades as infertility was the first most important contributor to a reduced QOL score followed by menstrual irregularities then weight problems. Recommendations: Upgrading women's knowledge concerning PCOS toward lifestyle modifications with a periodic screening of women for early detection and management of PCOS.