Background: A supportive clinical learning environment is very important for the transfer of learning in a clinical context .As well as it has critical effects on trainees and educators, skills, knowledge, create self- esteem and values. Aim of the study: was to assess the relationship between clinical learning environment and self-esteem among secondary nursing schools students at Ismailia City. Design: A descriptive correlational design was used in the study. Setting: the current study was conducted at all secondary nursing schools at Ismailia City. Sample: 243 nursing students. Tools for data collection: Data were collected using clinical learning environment questionnaire and Rosenberg self- esteem scale. Results: there was positive opinions toward total learning environment (89.7%). As well as, There was a positive statistical significant correlation between total opinions of student nurse about clinical learning environment and their total self-esteem levels as well as positive statistical significant correlation between total self-esteem levels and Premises of care in ward among student nurse. Conclusions: there was a statistical significant positive correlation between total student opinions about clinical learning environment and their total self-esteem levels. Recommendations: Encouraging students for discussion and acquiring knowledge and skills during clinical training. Ensuring clinical instructor involvement in monitoring practice and assessment of student competence and providing training courses for nursing student about motivating to learn, communicate and how to be self-confident during clinical training.