Background: Angioedema is an underdiagnosed illness with diagnostic and therapeutic challenges, characterized by episodic, sudden, and localized swelling of the skin and mucous membranes. It affects any area of the body and might be life-threatening. Physicians of different specialties may encounter angioedema patients in their daily practice. Objective: To assess physicians' knowledge and experience concerning diagnosis and emergency treatment of angioedema. Methods: we conducted an electronic survey involving 248 physicians of different specialties and degrees. The survey questions were designed to assess basic knowledge angioedema. The survey was distributed through online platforms and responses were collected and analyzed.  Results. Overall confidence reported by physicians regarding the evaluation of angioedema was 46.4% of participants, while only 34.3% had adequate practice about angioedema,  34.7% of physicians know the best definition of angioedema,  27% know the most suitable tests for diagnosis of a patient with suspected hereditary angioedema, 56.5% know the first step in emergency management of a patient with angioedema,  30.6 % of them know that adrenaline injection isn't mandatory treatment for all cases with angioedema and 27.8% know that antihistaminic drugs and corticosteroids are effective in allergic angioedema only. Emergency physicians and dermatologists had better practice about angioedema and 48.4% of physicians think that attending training on angioedema is important.  Conclusion: there was insufficient baseline knowledge about angioedema and inadequate practice during dealing with such cases among physicians so training programs and educational courses would be of value to raise awareness of angioedema and improve its outcome