Masonry-infilled reinforced concrete (RC) frames are prevalent in construction due to their robust strength and durability. However, the interaction between the infill and the frame can lead to various damage patterns, complicating the assessment of their seismic performance. Both analytical and experimental studies have been carried out to examine the behavior of these structures under in-plane lateral loading. This paper proposes a simplified micro-modeling approach using the commercial software ABAQUS to simulate the behavior of infilled RC frames with local brick samples. The proposed model is validated against experimental data, showcasing its ability to predict the load-displacement response of masonry-infilled RC frame structures. This research addresses a critical aspect of construction engineering: the seismic assessment of these frames is vital for ensuring structural safety and resilience. Utilizing the Concrete Damage Plasticity (CDP) model and the Drucker Prager criterion, the model effectively captures the complex behavior of infilled RC frames under monotonic loading. These findings enhance the understanding of the seismic behavior of these structures, offering valuable insights for better design and retrofitting strategies.