Abstract This study was performed during the 2019–2020 and 2021 seasons to examine the effect of the normal method (chelated form) versus the nanotechnology method on some microelements (Fe, Zn, and Mn) on the yield and both physical and chemical properties of the fruits of Zebda mango trees grown under Aswan region conditions. Spraying Zebda mango trees grown under Aswan region conditions three times with some micronutrients (Fe, Zn, and Mn) via the normal method (chelated form), each at 25 to 100 ppm, or via the nanotechnology method, each at 2.5 to 20.0 ppm, yield and fruit quality parameters were remarkably improved due to using some micronutrients (Fe, Zn, and Mn) via nano or normal forms relative to the control treatment. The promotion appeared in terms of increasing the yield per tree, weight, diameter, height, and thickness of fruit, flesh%, TSS%, total, reducing, and non-reducing sugars %, vitamin C, and reducing both total acidity% and fiber% in the fruits. In this respect, using some micronutrients (Fe, Zn, and Mn) via nanotechnology was superior to using them through normal methods. The best results with regard to the yield per tree and fruit quality of Zebda mango trees were obtained by treating the trees three times with some micronutrients (Fe, Zn, and Mn) via nanotechnology at 20.0 ppm.