Background: COVID-19 was declared by the WHO as pandemic around the world. Several researchers confirmed the COVID-19 impact on different body systems. The link between kidney injury and COVID-19 is still controversial. Aim: The purpose of this work was to assess acute kidney injury in COVID-19 cases. Patient and methods: A total of 200 confirmed COVID-19 infection patients with acute kidney injury were included. Medical files were reviewed and analyzed to explore the correlation between acute kidney injury and COVID-19 along with the outcome of the studied patients. Results: The patients' age ranged between 28 and 93 years with a mean of 68.1 ± 10.3 years. Out of those patients; about half of (n=104) cases males. Elevated inflammatory markers (leukocytosis), hypovolemia and severe COVID-19 infection were the most frequently reported risk factors for acute kidney injury. About one-fifth (n=41) of patients required renal replacement therapy. Also, about 60% of them were admitted to intensive care unit and about two-thirds (67%) of them deteriorated and died. The length of hospital stay ranged between 4 and 75 days with a median 10 days. Conclusion: One of the most frequent complications in hospitalized COVID-19 patients is acute renal injury. Strict follow up of patients with possible risk factors of AKI should be performed