Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is emerging one of the major causes of chronic liver damage that includes a wide spectrum of liver injury ranging from steatosis to steatohepatitis evolving to fibrosis.
Aim of the work:The purpose of our present study is to investigate the role of rosuvastatin in ameliorating the histological changes observed in animal model of HFD induced NAFLD.
Materials and Methods: forty adult male albino rats divided into 2 groups:control group, HFD group which divided into 3 groups HFD-control, crestor group and withdrawal group.
Results: Our results showed that rosuvastatin significantly ameliorated the histopathological lesions induced by HFD. Furthermore, HFD induced a significant elevation in blood glucose level ,lipid profile, liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)). This was significantly attenuated by rosuvastatin treatment and withdrawal of HFD.
Conclusion: These findings indicate that rosuvastatin and withdrawal of HFD possess a marked role in modulation of NAFLD.