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328212

Potential Cardio-protective Role of Dapagliflozin in Post Myocardial Infarction Patients

Article

Last updated: 29 Dec 2024

Subjects

-

Tags

Pharmacology

Abstract

Background:
Type II diabetes mellitus and ischemic heart disease (IHD) commonly coexist and can be dangerous. The sodium glucose cotransporter-II inhibitors (SGLT2i) are a new class of diabetes treatment that reduces IHD hospitalization and cardiovascular (CV) mortality. (SGLT2i) obviously results in a significant decrease in IHD risk; however, the mechanism of these effects is not clear. This study aimed to evaluate the possible treatment effect of dapagliflozin on diabetic patients with anterior (STEMI) treated by primary percutaneous coronary intervention (PCI).
Methods:
A randomized control trial enrolled 60 type II diabetic patients with anterior (STEMI) treated by primary (PCI) from both genders and their ages above 18 years old. The patients were categorized to two groups, Group (A) included 30 patients did not take dapagliflozin but they took the ordinary anti-ischemic & anti heart failure drugs also anti-diabetic medications. Group (B) enrolled 30 patients received dapagliflozin and they treated by ordinary anti-ischemic, anti-heart failure drug therapy and anti-diabetic medications.
Results:
In group (B) treated by dapagliflozin there was statistically highly significant improvement in LV systolic function by GLS, LVEF and LVEDD and LVESD in comparison with group (A) (P value<0.0001).
Conclusion:
Dapagliflozin played a substantial role in cardiac remodeling, including decrease the LVEDD, LVSD as well as improvement in left ventricular systolic function.

DOI

10.21608/aumj.2023.230195.1063

Keywords

STEMI, GLS, PCI, Dapagliflozin

Authors

First Name

mariam

Last Name

rafla

MiddleName

melad

Affiliation

medical pharmacology/ Faculty of medicine/Aswan university

Email

mariamrafla2022@gmail.com

City

Aswan

Orcid

-

First Name

Mahmoud

Last Name

Abdelraheem

MiddleName

Hamdy

Affiliation

medical pharmacology at faculty of medicine Assiut university

Email

mahmoudhamdy@yahoo.com

City

Assiut

Orcid

-

First Name

Mohammad

Last Name

Hareedy

MiddleName

Salem

Affiliation

medical pharmacology/faculty of medicine/assiut university

Email

dr-mohamedsalem@yahoo.com

City

assiut

Orcid

-

First Name

SAUD

Last Name

ELSAUGHIER

MiddleName

MOHAMED

Affiliation

cardiology department/Aswan hospital/Aswan university

Email

soud-elsoughier-66@yahoo.com

City

aswan

Orcid

-

Volume

3

Article Issue

2

Related Issue

44966

Issue Date

2023-12-01

Receive Date

2023-08-18

Publish Date

2023-12-01

Page Start

147

Page End

156

Print ISSN

2735-3109

Online ISSN

2735-3117

Link

https://aumj.journals.ekb.eg/article_328212.html

Detail API

https://aumj.journals.ekb.eg/service?article_code=328212

Order

328,212

Type

Original Article

Type Code

2,278

Publication Type

Journal

Publication Title

Aswan University Medical Journal

Publication Link

https://aumj.journals.ekb.eg/

MainTitle

Potential Cardio-protective Role of Dapagliflozin in Post Myocardial Infarction Patients

Details

Type

Article

Created At

29 Dec 2024