Background: Hair dye poisoning is becoming a major issue in Upper Egypt. The main component of hair dye toxicity is para-phenylenediamine (PPD). Objectives: Determine age, gender, clinical manifestations and outcome of hair dye poisoned patients. Methods: This study was conducted in Aswan University Hospital involving patients with acute hair dye poisoning from September 2019 to March 2020 then from September 2020 till July 2021 due to Corona virus. Demographic details, previous history of suicidal attempts, clinical manifestations, length of hospital stay and outcome were noted. Results: Total number of 50 cases was enrolled in this study in the age group of 15-53 years, 84% were females. The intent of ingestion among studied cases was suicidal in 82%. Among the studied cases, 46 cases were presented with cervico facial edema, 31 with black urine, 29 with dysphagia, 28 with dyspnea, 9 with convulsions and 6 with leg swelling. Tracheostomy was done on 35 patients, dialysis on 6 patients and 5 patients were put on mechanical ventilation.  Upon treatment, 40 patients discharged from the hospital. Ten cases died. Conclusions: PPD causes multi-organ toxicity. ARF is one of the leading causes of mortality