One of the most common consequences following endoscopic sinus surgery is postoperative discomfort. There is evidence to support the use of intranasal sphenopalatine ganglion (SPG) block to lessen the requirement for systemic analgesia. Although several therapeutic compounds have been researched, lidocaine and bupivacaine remain popular therapy alternatives due to their accessibility and affordability. Bilateral SPG block as adjuvants to general anaesthesia during endoscopic endo-nasal trans-sphenoidal hypophysectomy is a safe and successful approach. By using a bilateral SPG block regulates hypotensive method, treats insufficient intraoperative analgesia, decreases intraoperative blood loss, and improves surgical field vision, it aids to the stability of hemodynamics during surgery. Additionally, SPG block reduced the need for analgesics after surgery and has promoted a quicker recovery, which is essential for an early neurological evaluation.