Background: Varicose veins are common, and their management has undergone a number of changes over the years. Surgery has been the traditional treatment option, but towards the 21st century, new endovenous thermal ablation techniques, namely, radiofrequency ablation, was introduced which have changed the way varicose veins are treated. Cyanoacrylate ablation is the newest nonthermal vein ablation technique, Aim and objectives; to compare between the efficacy and clinical outcomes of CA and RFA for patient with lower limb varicose vein with incompetent SFJ, Subjects and methods; This is an open labeled RCT, conducted on patients presented to our department, with varicose veins with Incompetent Sapheno-femoral junction, aged > 18 years, and dilated GSV. Participants were randomly allocated into two groups, Group A: underwent RFA and Group B: underwent CA. Result; In this study we included 40 patients. The mean operative duration for group A was (15.25±0.55) and for group B (19.52 ± 0.95). There was very highly statistically significant improvement in VAS score over time in both group. Conclusion: CA offers comparable success rates with lower midterm complication rates as RFA.