Manufacturing companies seek to improve competitiveness through continuous improvement in process productivity and product quality using Lean Six Sigma (LSS) methodology, which is a methodology that integrates Lean Manufacturing and Six Sigma strategies, which means that the principles, philosophies and tools of both methodologies are also united in one approach. This systematic review aims to explore the most popular topics within LSS in manufacturing over the past ten years (2014 to 2023), and to identify and analyze any gaps. Results found that LSS helps in improving quality, increasing sigma level, reducing non-added value, increasing productivity, reducing production costs, and improving customer satisfaction. Furthermore, the results can be used for a systematic literature review by researchers and manufacturing leaders before embarking on a journey of continuous improvement. Finally, this study proposed a LSS framework for the manufacturing domain, which includes 40 steps. Various tools like process mapping, KPIs, OEE, sigma level, seven quality control tools, process time analysis, value stream mapping, kaizen, 5S, brainstorming, and standard work have been used at different phases of DMAIC.