Photovoltaic panels (PV) are considered one of the solutions to face climate change and pollution. A PV/Thermal system is used as a result to raise the output power of the PV modules by decreasing their temperatures. This work includes numerical and experimental outputs, a comparison between the electro-thermal behaviours of water and different percentages of AL2O3 Nano-water (0.001 & 0.01) pass through a new back pipe structure (pancake) installed under the PV module is presented. Comsol Multiphysics and MATLAB simulators are utilized to apply the model. The experimental work runs for both Nanoparticle concentrations compared with water. The pumping power consumption is approximately 1% from the average output power of the system. The thermal results for 0.01 %wt of AL2O3 Nano-water show that the PV module temperature decreased about 14.04 % and 8.8 % compared with water and 0.001 %wt Alumina, respectively. In addition, the difference in water temperature is increased by about 21.6 % and 6.7 % for two different concentrations compared with water. That leads to enhancement in the module's daily output power up to 14.6 % by using 0.01 wt% AL2O3 Nano fluid compared with cooling water.