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Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens

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Last updated: 05 Jan 2025

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Abstract

In recent decades, microbial resistance to antimicrobial drugs has emerged as a global health crisis. Therefore, it is crucial to develop alternative therapeutic strategies to address the growing threat of multi-drug resistant (MDR) pathogens. Researchers and clinicians are increasingly focusing on plant-based products due to their antibiotic properties and lack of associated antibiotic resistance. Plant-based nanoparticles present several benefits, including their natural origin, biocompatibility, and potential for targeted delivery. Our aims in this review were exploration of the complexities and limitations of plant-based phytochemical extraction processes and addressing the challenges of synthesizing nanoparticles for combating multidrug-resistant (MDR) pathogens. It also examined the effectiveness of phyto-based nanoparticles in drug delivery systems to treat MDR infections; both alone and in combination with antibiotics, and provided a critical assessment of their potentials as a research avenue. For this, we have taken the diverse methodologies that were previously used to select the best possible process to tackle MDR pathogens using plant extracts. Although using plant-derived products and nanoparticles is a novel approach to address the antimicrobial drug resistance; however, detailed researches are necessary to explore their antibacterial attributes. Specifically, transcriptome profiling should be employed to identify therapeutic molecules from plant-based products that can effectively combat MDR bacteria before synthesis of nano-drugs. The outcomes of this study will enable the researchers to obtain the best approaches to tackle MDR pathogens through using the nano-based phytochemicals.

DOI

10.21608/nrmj.2024.306911.1663

Keywords

Phyto-based nanoparticles, MDR pathogens, tackling strategies, Nano drugs

Authors

First Name

Subhasmita

Last Name

Mallik

MiddleName

-

Affiliation

Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India

Email

msubhasmita1998@gmail.com

City

-

Orcid

0009-0000-8354-8909

First Name

Samikshya

Last Name

Nayak

MiddleName

-

Affiliation

Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India

Email

suminayak59@gmail.com

City

-

Orcid

0009-0003-8056-5895

First Name

Arpita

Last Name

Panda

MiddleName

-

Affiliation

Department of Zoology, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India

Email

pandaarpita13@gmail.com

City

-

Orcid

0009-0004-8812-993X

First Name

Smrutirekha

Last Name

Behera

MiddleName

-

Affiliation

Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India

Email

beherasmrutirekha2002@gmail.com

City

-

Orcid

0009-0005-9582-6984

First Name

Kamalakanta

Last Name

Swain

MiddleName

-

Affiliation

Department of Zoology, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India

Email

kamalakanta0010@gmail.com

City

-

Orcid

0009-0004-1943-8448

First Name

Archita

Last Name

Patra

MiddleName

-

Affiliation

Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India

Email

patraarchita1@gmail.com

City

-

Orcid

0009-0004-0601-5622

First Name

Rukmini

Last Name

Mishra

MiddleName

-

Affiliation

Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India

Email

rukmini.mishra@cutm.ac.in

City

-

Orcid

0000-0001-9692-212X

First Name

Jatindra

Last Name

Nath Mohanty

MiddleName

-

Affiliation

Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India

Email

jatindranath.mohanty@cutm.ac.in

City

-

Orcid

0000-0001-9228-8395

Volume

8

Article Issue

5

Related Issue

50276

Issue Date

2024-09-01

Receive Date

2024-08-01

Publish Date

2024-09-20

Page Start

2,604

Page End

2,631

Print ISSN

2537-0286

Online ISSN

2537-0294

Article File

NRMJ_Volume 8_Issue 5_Pages 2604-2631.pdf

PDF . 775.5kB

Link

https://nrmj.journals.ekb.eg/article_380744.html

Detail API

https://nrmj.journals.ekb.eg/service?article_code=380744

Order

380,744

Type

Review Article

Type Code

2,338

Publication Type

Journal

Publication Title

Novel Research in Microbiology Journal

Publication Link

https://nrmj.journals.ekb.eg/

MainTitle

Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens

Details

Type

Article

Created At

28 Dec 2024