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357929

A review on drug resistance patho-mechanisms in ESKAPE bacterial pathogens

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Last updated: 05 Jan 2025

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Abstract

The escalating incidence of nosocomial infections stemming from ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) bacterial pathogens presents a formidable clinical challenge globally, affecting both the developed and developing nations. These pathogens, which are distinguished by their robust antibiotic resistance mechanisms, pose a significant threat to the public health. Their ability to evade traditional antimicrobial treatments underscores the urgent need for novel therapeutic stratifies or alternative approaches to mitigate their negative impact. Understanding the intricate mechanisms underpinning antibacterial resistance in ESKAPE bacteria is paramount for developing effective interventions. Enhanced insights into these mechanisms will facilitate the prediction of resistance patterns among the multidrug-resistant pathogens, thereby guiding the development of targeted therapies and preventive measures. Consequently, comprehensive efforts are needed aiming at unraveling the intricacies of antibacterial resistance in ESKAPE pathogens that are imperative to safeguarding the public health. The aim of the present review was to highlight the patho-mechanisms of ESKAPE bacteria towards the different antibiotics and genes involved in multi-drug resistance.

DOI

10.21608/nrmj.2024.287047.1549

Keywords

antibacterial resistance, ESKAPE, Nosocomial infection, multidrug resistance, pathophysiology

Authors

First Name

Apoorva

Last Name

Jain

MiddleName

-

Affiliation

SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, 5th Floor, Specialty Block, Manjushree Building, Manjushree Nagar, Sattur- Dharwad-580009, Karnataka, India

Email

apoorvajain0502@gmail.com

City

-

Orcid

0000-0002-7643-9541

First Name

Ajay

Last Name

Kumar Oli

MiddleName

-

Affiliation

SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, 5th Floor, Specialty Block, Manjushree Building, Manjushree Nagar, Sattur- Dharwad-580009, Karnataka, India

Email

ajaykumar@sdmuniversity.edu.in

City

-

Orcid

0000-0002-9634-2819

First Name

Sughosh

Last Name

Kulkarni

MiddleName

-

Affiliation

Department of Microbiology, SDM College of Medical Sciences and Hospital, Shri Dharmasthala Manjunatheshwara University, SDMCMSH Campus, Manjushree Nagar, Sattur-Dharwad-580009, Karnataka, India

Email

dr.sughosh86@gmail.com

City

-

Orcid

0000-0002-3408-6418

First Name

Raghavendra

Last Name

D. Kulkarni

MiddleName

-

Affiliation

Department of Microbiology, SDM College of Medical Sciences and Hospital, Shri Dharmasthala Manjunatheshwara University, SDMCMSH Campus, Manjushree Nagar, Sattur-Dharwad-580009, Karnataka, India

Email

-

City

-

Orcid

0000-0002-8460-5079

First Name

Kelmani

Last Name

Chandrakanth

MiddleName

-

Affiliation

Department of Biotechnology, Jnana Ganga Campus, Gulbarga University, Kalaburagi-585106, Karnataka, India

Email

-

City

-

Orcid

0000-0003-1400-0944

Volume

8

Article Issue

3

Related Issue

47434

Issue Date

2024-05-01

Receive Date

2024-05-03

Publish Date

2024-05-02

Page Start

2,435

Page End

2,451

Print ISSN

2537-0286

Online ISSN

2537-0294

Article File

NRMJ_Volume 8_Issue 3_Pages 2435-2451.pdf

PDF . 394.6kB

Link

https://nrmj.journals.ekb.eg/article_357929.html

Detail API

https://nrmj.journals.ekb.eg/service?article_code=357929

Order

357,929

Type

Review Article

Type Code

2,338

Publication Type

Journal

Publication Title

Novel Research in Microbiology Journal

Publication Link

https://nrmj.journals.ekb.eg/

MainTitle

A review on drug resistance patho-mechanisms in ESKAPE bacterial pathogens

Details

Type

Article

Created At

28 Dec 2024