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From gut to brain: Deciphering the impact of gut microbiota on neurological health

Article

Last updated: 28 Dec 2024

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Abstract

The Gut-Brain Axis is a complex and fascinating concept elucidating the two-way communication between gut microbiota and the central nervous system, encompassing diverse mechanisms with profound implications on neurological health. Situated in the gastrointestinal tract, the gut microbiota, a diverse bacterial community, which communicates with the brain through various processes, including neurotransmitter and neuropeptide synthesis, immune system modulation, and involvement of the vagus nerve. These interactions not only impact digestion but also influence emotions, cognition, and behavior. Recent research has revealed the significant influence of gut microbiota on the neurological health, establishing connections between alterations in the gut microbiota composition and the prevailing conditions such as depression and neurodegenerative diseases. This understanding sheds new light on the pathophysiology of neurological disorders, marking the gut-brain axis as an exciting frontier in neuroscience and medicine. The aims of this study were to investigate and elucidate the intricate interplay between the gut microbiota and neurological health, and exploring the mechanisms of communication along the gut-brain axis. As research progresses, the potential for groundbreaking strategies to prevent and treat the neurological disorders becomes increasingly apparent. This comprehensive review delves into the nuanced world of the gut-brain axis, providing insights into the intricate relationship between the gut and the brain. Additionally, this review delves into potential therapeutic implications, exploring the use of probiotics, prebiotics, and dietary interventions to modulate gut microbiota for enhancement of the neurological well-being.

DOI

10.21608/nrmj.2024.273319.1479

Keywords

Gut-brain axis, gut microbiota, vagus nerve, depression, Neurological health

Authors

First Name

Gopinath

Last Name

R.

MiddleName

-

Affiliation

Department of Microbiology, Government Theni Medical College, Theni, Tamil Nadu-625512, India

Email

-

City

-

Orcid

0000-0003-0118-6831

First Name

Arundadhi

Last Name

M.

MiddleName

-

Affiliation

Department of Microbiology, Government Theni Medical College, Theni, Tamil Nadu-625512, India

Email

-

City

-

Orcid

-

First Name

Dhanasezhian

Last Name

A.

MiddleName

-

Affiliation

Department of Microbiology, Government Theni Medical College, Theni, Tamil Nadu-625512, India

Email

-

City

-

Orcid

0009-0009-6138-2536

First Name

Thangam

Last Name

G. Sucila

MiddleName

-

Affiliation

Department of Microbiology, Government Theni Medical College, Theni, Tamil Nadu-625512, India

Email

drgsucilamicro@gmail.com

City

-

Orcid

0009-0002-4964-0941

Volume

8

Article Issue

2

Related Issue

46809

Issue Date

2024-03-01

Receive Date

2024-02-28

Publish Date

2024-03-22

Page Start

2,339

Page End

2,353

Print ISSN

2537-0286

Online ISSN

2537-0294

Link

https://nrmj.journals.ekb.eg/article_346872.html

Detail API

https://nrmj.journals.ekb.eg/service?article_code=346872

Order

346,872

Type

Review Article

Type Code

2,338

Publication Type

Journal

Publication Title

Novel Research in Microbiology Journal

Publication Link

https://nrmj.journals.ekb.eg/

MainTitle

From gut to brain: Deciphering the impact of gut microbiota on neurological health

Details

Type

Article

Created At

28 Dec 2024