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327188

Complex ecological approach to cystic fibrosis respiratory infections

Article

Last updated: 05 Jan 2025

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Tags

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Abstract

Cystic fibrosis (CF) is one of the most common genetic disorders; resulting in a wide variety of complications, including respiratory infections. Such infections are often ineffectively treated within the framework of a classical paradigm of the infectious process. However, little attention is paid to the unique microecological conditions that are formed in CF respiratory tract. This study aimed to exploring the microecological conditions and to finding out how they may influence the pathogenesis of CF infections. These conditions emerge under the influence of local disruptions in the respiratory functions; inflammatory processes, and complicated relations of the individual microorganisms between each other and between the human bodies as their ecological substrates. As a result, microorganisms that are usually safe for the healthy people become extremely dangerous for CF patients; having adapted to a new ecological niche and having got definite resource advantage, which is attributed to the respiratory tract tissue destruction. Additionally, it is still unknown; how do the anaerobic microbes contribute to CF infections, and whether they collaborate with the traditional CF pathogens or compete with them. In this article, we are analyzing CF respiratory infections from the ecological perspective and proposing in our opinion a more comprehensive picture of their pathogenesis.

DOI

10.21608/nrmj.2023.327188

Keywords

Cystic fibrosis, Respiratory microbiota, Bacterial Communities, Bacterial successions

Authors

First Name

Dmitriy

Last Name

V. Alekseev

MiddleName

-

Affiliation

Research and Educational Professional Center for Genetic and Laboratory Technologies, Samara State Medical University, Gagarina st. 20, Samara, Russia

Email

d.v.alekseev@samsmu.ru

City

-

Orcid

0000-0002-8864-4956

First Name

Artem

Last Name

V. Lyamin

MiddleName

-

Affiliation

Research and Educational Professional Center for Genetic and Laboratory Technologies, Samara State Medical University, Gagarina st. 20, Samara, Russia

Email

-

City

-

Orcid

0000-0002-5905-1895

First Name

Karim

Last Name

A. Kayumov

MiddleName

-

Affiliation

Research and Educational Professional Center for Genetic and Laboratory Technologies, Samara State Medical University, Gagarina st. 20, Samara, Russia

Email

-

City

-

Orcid

0000-0002-9614-7255

Volume

7

Article Issue

6

Related Issue

44294

Issue Date

2023-11-01

Receive Date

2023-10-26

Publish Date

2023-11-01

Page Start

2,229

Page End

2,247

Print ISSN

2537-0286

Online ISSN

2537-0294

Link

https://nrmj.journals.ekb.eg/article_327188.html

Detail API

https://nrmj.journals.ekb.eg/service?article_code=327188

Order

327,188

Type

Review Article

Type Code

2,338

Publication Type

Journal

Publication Title

Novel Research in Microbiology Journal

Publication Link

https://nrmj.journals.ekb.eg/

MainTitle

Complex ecological approach to cystic fibrosis respiratory infections

Details

Type

Article

Created At

28 Dec 2024