This investigation was conducted to estimate the impact of pre-harvest application of zinc, magnetite, selenium and silver nanoparticles at (30, 60 and 90 ppm) for each on yield and fruit quality as compared with untreated fruits of “Zaghloul" date palm during (2018 and 2019) seasons. All treatments were sprayed on bunches and performed three times at the beginning of growth, after fruit setting, and at one month later. The sprayed fruits were harvested at Khalal stage in September, yield and quality were evaluated at harvest day. Results showed that all treatments enhanced yield and fruit quality as the best treatment was zinc oxide nanoparticles at 90 ppm as increased yield, bunches weight, fruit weight, flesh weight and fruit firmness; also gave the highest total soluble solids, total sugars and total anthocyanin content. Moreover, gave the lowest decreased seeds weight as compared with the control. Furthermore, the metal concentrations in sprayed fruit with some nanoparticles were found within the permissible limits regulated for health standard. In addition, health risk index for zinc, magnetite, selenium and silver nanoparticles were less than 1, which indicated to “Zaghloul" date palm fruits supplied with ZnONPs, Fe3O4NPs, SeNPs and, AgNPs, were free of risks on human health and can be considered as appropriate strategy for improving yield, nutritional status and quality of “Zaghloul" date palm.