Infection prevention and control now is mandatory in all medical units and specialties with a variable process according to each. Radiology department is one of the front lines specialties in dealing with wide variety of patients and diseases which needs a quite different measures for controlling infection especially due to the special nature of its procedures and machines. This review article aims to explain basics and essentials of infection prevention and control in radiology department. understanding of basics and Essentials of Infection control in radiology department is essential for all medical and paramedical team working in it.Consulting I P C department is the best solution for updates and dealing with complicated situations.The best disinfector of every medical imaging machine is that recommended by its vendor, while other surfaces have the better disinfector according to its nature. Consulting I P C department is the best solution for updates and dealing with complicated situations.