Introduction : Neonatal hyperbilirubinemia (NH) is a common problem which occurs in about 60% of fullterm newborns and 80% of premature newborns during the first week of life. Actually, accumulation of bilirubin in the brain may result in temporary or permanent brain injury. So, early diagnosis and proper treatment of jaundice is of great significance. Several risk factors had been known as the determinants of jaundice including ; maternal and neonatal risk factors.

Aim of the study: was to assess neonatal hyperbilirubenemia outcome, and its relationship to neonatal and maternal risk factors in Minia Governate.

Subjects and Methods:

It was a prospective study included one hundred sixty nine neonates with clinical jaundice. All of them had total serum bilirubin level> 2mg/dl and were admitted in different Neonatal Intensive Care Units (NICUs) in Minia Governorate during the period from August 2021 to May 2022.All the involved newborns were subjected to a structured questioner, clinical examination and laboratory investigations. They were followed up to detect their outcomes (survival , mortality or discharged with complications. Finally ,we study the relationships between these risk factors ant different outcomes.

Results: Eighty seven (51.5%) of neonates were full term and eighty two(48.5%)were preterm. Neonates.As regard the outcomes neonataes with exaggerated physiological jaundice were statically significantly recovered more than those with other causes.Furtherly , neonates with sepsis were more significantly died or developed complications than the neonates with other etiology of hyperbilirubinemia. Prematurity.low weight ,previuos history of jaundiced neonates, low APGAR score wer associated with poor outcomes.