Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused coronavirus disease 2019 (COVID-19), infected more than 126 million individuals, and caused more than 6 million fatalities globally. Diabetes is chronic endocrine/metabolic disease with heterogeneous etiologies, clinical presentations, and associated complications. caused mainly by insulin deficiency and/or insulin resistance. It remains unknown whether diabetes alone or in conjunction with accompanying illnesses contributes to the poorer prognosis.

Patients and Methods:

This study is a retrospective observational study, during the period from May 2021 to May 2022. This study included 300 laboratory-confirmed SARS-Cov-2 infections. Attended the isolation wards in our internal medicine department at Minia university hospitals.

Results: We found that in individuals with COVID-19. Diabetes and COVID-19 may interact in both directions, as SARS-CoV-2 infection may exacerbate pre-existing diabetes and may predispose non-DM people to develop diabetes. In addition, SARS-CoV-2 pancreatic cell invasion induces -cell autoimmunity in susceptible individuals, resulting in type 1 diabetes and Increased COVID-19 severity.

Conclusion: In individuals with COVID-19. Diabetes and COVID-19 may interact in both directions, Also, newly diagnosed diabetes

In this study. Diabetes was more prevalent in individuals with severe COVID-19, also as regards the comorbidities, Diabetes patients have a higher rate of complications such as cardiovascular disease, pulmonary disease, cancer, and other chronic conditions .Also, In our study, the individuals with NIDDM had greater inflammatory markers additionally, the complications were obvious to be much more in recently diagnosed diabetics