Liver harm is discovered in up to half hospitalized COVID19 patients and result either from actions of SARS-CoV2 or from medicine treatment. the current paper introduces Associate describes the pathways by SARS-CoV-2 resulting in liver injury. this will be caused by direct binding of the virus and native actions in cholangiocytes, however might also indirectly result from the final state of drive and general inflammation in COVID-19 patients. Aim of the study: The aim of the current study to evaluate liver abnormalities and the effect of these changes in prognosis of patients infected with Covid-19 in Minia University hospital. Materials& Methods: This study is a a prospective study, during the period from May to December, 2021.This study included 325 patients with covid-19 Minia university hospitals. Results: Significantly increased levels of TB and DB  (p