Background: Each year, millions of gastrointestinal anastomoses are created worldwide. Anastomotic leakage after the creation of a gastrointestinal anastomosis remains an important complication in gastrointestinal surgery.

Aim: To compare between intestinal resection reanastomosis with use of tissue adhesive modified cyanoacrylate (Glubran 2) in Group B or without in Group A as regard intestinal leakage , operative time , hospital stay.

Patients and methods: This prospective controlled clinical study was carried out on 40 patients of intestinal resection reanastomosis with use of tissue adhesive (Glubran 2) in Group B or without adhesive material in Group A.

Results: Postoperative outcomes show some variations between two groups, but most differences do not reach statistical significance p<0.05. Group B had a higher rate of ICU admissions (25% vs 15% in Group A). More patients in Group A required blood transfusions (70% vs 50% in Group B), but this difference does not reach statistical significance, Group A had a notably longer median hospital stay of 10 days compared to 7 days for Group B, and this difference shows statistical significance (p=0.05), Regarding the incidence of leakage between studied groups, the result was not statistically significant as only 3 cases in group A compared to only 1 case in group B had leakage .

Conclusion: We concluded there was a difference in postoperative leakage between groups A and B, without statistically significant difference. However, no statistically significant differences were found in ICU admission, postoperative blood transfusion operation, hospital stay, DVT, wound infection, quality of surgical specimen.