Background: Single anastomosis sleeve jejunal (SASJ) bypass is a recently developed bariatric technique. This procedure aims to keep passing to the duodenum to reduce the associated nutritional deficiency and to allow endoscopic treatment of choledocholithiasis. This study aimed to evaluate the efficacy of the SASJ bypass in the treatment of morbidly obese patients. Methods: 50 morbidly obese patients underwent SASJ bypass, All patients were followed up at 1, and 6 months. We evaluated BMI, post-operative complications, and obesity-related comorbidities. Results: The mean age of enlisted cases was 35.2 years, and the mean BMI was 49.8kg/m². Of the patients, 37(74%) had type two DM, and 16(32%) were hypertensive. 10 (20%) cases had osteoarthritis, 12(24%) cases had obstructive sleep apnea, and 4(8%) cases had GERD. Intraluminal bleeding occurred in two cases (4%). and three patients developed biliary gastritis (6%). One patient (2%) developed DVT. The percentage of EWL was 58.2% after 6 months Normalization of blood glucose level occurred within 6 months after surgery in 86.4 % of diabetic patients. Hypertension improved in all hypertensive patients. Conclusion: Laparoscopic SASJ bypass is an effective, safe, and technically easy operation for treating morbid obesity and comorbid conditions with less nutritional deficiencies.

Keywords: SASI · Loop bipartition · metabolic surgery · Sleeve jejunal bypass.