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358538

Assessment of the relation between IL-6 expression and the severity of covid-19 infection

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Immune modulation and inflammatory mediators.

Abstract

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Elevated levels of proinflammatory cytokines, such as interleukin-6 (IL-6) may affect disease severity and progression because of the cytokine storm. This study aims to assess the association between the level of IL-6 expression and the severity of COVID-19 infection.

Methods: In total, 100 individuals (50 patients and 50 healthy controls) were recruited for this study. RNA was extracted from peripheral blood leukocytes of patients to determine the level of IL-6 expression by Real-Time Quantitative Reverse Transcription PCR (qRT-PCR).

Results: There was a significant difference in the level of IL-6 expression in severe cases than in mild and moderate COVID-19 cases.

Conclusion: The study concluded that IL-6 plays an important role in the pathogenesis and outcome of the disease. So, it can be used as a diagnostic marker.

Keywords: COVID-19; IL-6; qRT-PCR.

DOI

10.21608/mjmr.2024.275443.1688

Keywords

Keywords: COVID-19, IL-6, qRT-PCR

Authors

First Name

Alyaa

Last Name

Abdelkader

MiddleName

Ezz

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Minia University, Minia, Egypt

Email

alyaaezz.yk@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Shoukry

MiddleName

E

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Minia University, Minia, Egypt

Email

mahmoud.youssef@med.miniauniv.edu.eg

City

Minia

Orcid

-

First Name

Noha

Last Name

Hassuna

MiddleName

Anwar

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Minia University, Egypt

Email

nohaanwar@mu.edu.eg

City

Minia

Orcid

-

First Name

Mohammed

Last Name

Abdel Kareem

MiddleName

Zain-Alabedeen

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.

Email

mz.micro2010@yahoo.com

City

Minia

Orcid

-

First Name

Shaimaa

Last Name

Zaki

MiddleName

Hassouna

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Minia University, Minia, Egypt

Email

shaimaa.hasona@mu.edu.eg

City

Minia

Orcid

0009-0001-1971-4949

Volume

35

Article Issue

1

Related Issue

46232

Issue Date

2024-01-01

Receive Date

2024-04-19

Publish Date

2024-01-01

Page Start

122

Page End

127

Online ISSN

2682-4558

Article File

MJMR_Volume 35_Issue 1_Pages 122-127.pdf

PDF . 293.9kB

Link

https://mjmr.journals.ekb.eg/article_358538.html

Detail API

https://mjmr.journals.ekb.eg/service?article_code=358538

Order

17

Type

Original Article

Type Code

2,212

Publication Type

Journal

Publication Title

Minia Journal of Medical Research

Publication Link

https://mjmr.journals.ekb.eg/

MainTitle

Assessment of the relation between IL-6 expression and the severity of covid-19 infection

Details

Type

Article

Created At

28 Dec 2024