Background: non-communicable diseases are preventable diseases that are currently the leading causes of death in Egypt. Non-communicable diseases and their related risk factors represent a significant burden on the individuals and the health system in Egypt. Aims of study: Detection of the frequency of non-communicable diseases and their associated risk factors among staff members of Minia University. Methods: This study is a cross sectional study conducted for detection of the frequency of non-communicable diseases and their associated risk factors among staff members of Minia University.240 participants were included in the study, using administered questionnaire which included demographic characteristics. Weight, height, blood pressure, cholesterol level, HA1c and random blood sugar were measured. Also, kidney function tests, serum albumin and urine analysis were done. BMI was calculated as weight (kg) divided by the square of height (m2). Results: The frequency of chronic kidney disease (CKD) among staff members of Minia University was 92.5%. Nearly two thirds of CKD patients were males while one third was female. Also, the current study demonstrated a relation between CKD with systolic blood pressure (SBP) and hypercholesterolemia. The frequency of CKD increased with age. The frequency of diabetes mellitus (DM) among staff members of Minia University was 42.9%. There was a significant relation between DM and SBP. While the frequency of hypertension was 75.4%. It was more prevalent in males than in females. Conclusions: The frequency of CKD among staff members of Minia University was 92.5%. Frequency of DM was 42.9%. Nearly three-quarters of participants had hypertension.