Background: The embryonic phase is crucial in humans and has the ability to impact adult phenotypic characteristics. This study aims to investigate the impact of L-Arginine supplementation on the treatment of intra-uterine fetal growth restriction at Minia Maternity University Hospital. the specific focus of this study is on examining the effects of L-Arginine supplementation.

Methods: Summary A study was carried out on a cohort of 60 pregnant women who were diagnosed with intrauterine growth restriction (IUGR) at the Department of Obstetrics and Gynecology, Minia Maternity University Hospital. The participants were categorized into two cohorts: Group A comprised of 30 pregnant women who were administered Arginine, whereas Group B included of 30 pregnant women who received standard care.

Results: Upon review, there were no notable disparities in age, BMI, parity, gravidity, and GA between the two groups (P-value > 0.05). Women who were administered arginine experienced a statistically significant increase in IU fetal movement compared to those who were not administered arginine (P-value < 0.05). Female participants who were given arginine experienced a statistically significant decrease in post-treatment UA Doppler readings compared to those who did not receive arginine (P-value < 0.05).

Conclusion: Administering L-Arginine to pregnant women diagnosed with intrauterine growth restriction (IUGR) can enhance the fetal condition and enhance the neonatal prognosis following birth. This can be achieved by extending the duration of pregnancy and giving birth to a baby with a greater birth weight, improved Apgar score.

Keywords: Intrauterine growth restriction (IUGR), L-Arginine Supplementation.