Background: Colorectal cancer ranks the 7th among both genders, accounting for about 5% of all malignant tumors, according to Globocan statistics, for exploring the cancer burden in Egypt, 2020, Studies on the epidemiology of colorectal cancer in Minia governorate - one of the densely populated areas in upper Egypt -are very limited.

Purpose: This study intent is to highlight the Clinicoepidemiological aspects of colorectal cancer in Minia Governorate.

Methods: a retrospective study of all colorectal cancer patients from Minia Governorate who were diagnosed from January 2015 to December 2019. The study included all patients having histopathologically proven colon, rectal and colorectal cancer. The study has been conducted at different oncology treatment centers in Minia Governorate including Minia university hospital, Minia oncology center, general authority of health Insurance and different private cancer treatment centers. All data were studied as regards to epidemiological, clinical, pathological parameters. Data analysis was carried out using IBM Statistical Package for Social Sciences software (SPSS).

Results: there were 660 patients with colorectal cancer from Minia Governorate during the years 2015-2019, representing an incidence of 4.89% of all cancers. Male to Female ratio was 1:1.12. Mean age at diagnosis was 49 years. Minia, Abu Qurqas and Samalout had the highest number of cases with 159, 104,100 cases respectively. Ascending colon, rectum and sigmoid colon represented the most common sub sites (17.42%), (16.82%), (15.45%) respectively.

Conclusions: our results support evidence that there was higher female to male ratio having colorectal cancer which may due to environmental and/or lifestyle factors.