Background: Different techniques for management of spasticity have been proposed, including positioning, splinting and casting, cryotherapy and electrical stimulation, most of them have little evidence to support their application. This study aims at studying the therapeutic effect of botulinum toxin injection in patients with spasticity of different etiologies, recruited from the Neurology outpatient clinic of Minia University Hospital, using different evaluation tools. Methods: Thirty four patients (15 males, 19 females) were included in the period between October, 2022 and January, 2023. Their age ranged from 6 to 62 years, suffering from different upper motor neuron syndromes. Patients were subjected to history taking and neurological examination. Patients were evaluated by Modified Ashworth Scale, Barthel Index and Cochin Scale just before injection, 6 and 12 weeks after injection. Results: According to the three used evaluation tools, patients showed highly significant improvement when examined in the 2^nd visit (6 weeks after injection) in comparison with the 1^st visit (just before injection). Improvement continued significantly also when patients examined in the 3^rd visit (12 weeks after injection) in comparison with the 1^st visit. But the difference in improvement between the 3^rd and 2^nd visits was not statistically significant. Conclusion: Botulinum toxin is recommended in treatment of spasticity. It was simple, effective and safe.